Research

We develop and integrate cutting-edge spatial multi-omics technologies to simultaneously investigate gene expression, proteins, peptides, metabolites, and lipids within intact tissues. Our goal is to establish standardized workflows that bridge molecular information across multiple omics layers, enabling comprehensive insights into tissue organization and biological function. 

Functional Mass Spectrometry Imaging (fMSI) combines on-tissue enzymatic reactions with MALDI imaging to visualize the spatial activity of enzymes and other bioactive molecules. Rather than measuring molecular abundance alone, fMSI captures biochemical function directly within native tissue, providing unique insights into enzyme regulation, tissue heterogeneity, and disease-associated molecular processes. 

We develop highly multiplexed mass spectrometry imaging (Multiplexed MSI) approaches that combine antibody-based target recognition with mass-tag technology to simultaneously visualize numerous protein biomarkers within intact tissues. Our aim is to establish scalable, standardized workflows that bridge histopathology and molecular imaging, enabling high-dimensional spatial proteomics for biomedical research, biomarker discovery, and precision medicine. 

We combine state-of-the-art transcriptomics and proteomics to decode the molecular complexity of animal venoms across diverse taxa. Our aim is to establish standardized venomics workflows that identify novel toxins, investigate venom evolution and functional diversity, and provide a foundation for applications ranging from drug discovery to next-generation antivenom development.